Adnan Custovic is Professor of Paediatric Allergy at Imperial College London. His research has focused upon the origins and natural history of asthma and allergy across the life-course, with an emphasis on prevention and translation for patient benefit. His research findings are of great practical significance and have informed and changed national and international guidelines on asthma prevention/management. His studies in food allergy substantially impacted clinical practice. His discovery that IgE-response to peanut allergen Ara h 2 is much more predictive of true peanut allergy than standard tests using whole allergen extract marked the start of the component-resolved diagnostics as the new gold standard in clinical practice. His current research programme combines world-leading expertise in birth cohorts and statistical machine learning and capitalises on the recent developments within the field of computer sciences to provide powerful new tools that are well suited to the challenge of integration of different scales of data (from molecular-level to population-level), and different levels of directness of measurement of factors. In BT, he leads Workstream 5 which uses longitudinal data on childhood wheezing and genetics generated from five established large UK birth cohorts in STELAR consortium to determine if there is a genetic signal in the pathways and molecules identified in Workstreams 2-4, and use Workstream 1 samples to determine if the different epidemiological/genetic wheeze phenotypes identified in STELAR have corresponding functional readouts in vitro.